The BIG TrAC project aims to develop innovative, non-viral nanocarriers for gene delivery by integrating polymer chemistry and membrane biophysics. The collaboration between Sorbonne University and the University of Milan focuses on understanding how polymer-based nanoparticles interact with biomimetic cellular membranes, in order to optimize their efficiency and reduce toxicity.
By combining advanced synthesis strategies with state-of-the-art biophysical characterization techniques (including neutron and X-ray scattering), the project seeks to uncover the mechanisms governing nanoparticle–membrane interactions across different biological environments.
The visiting period will also contribute to the development of a “spread laboratory” model between Paris and Milan, promoting continuous exchange of protocols, data, and expertise. In parallel, dedicated lectures and seminars for Master’s and PhD students will foster an interdisciplinary learning environment at the interface of chemistry, physics, and nanomedicine.
Ultimately, BIG TrAC aims to contribute to the development of safer and more accessible gene delivery systems, while strengthening research integration and education within the 4EU+ framework.
"I expect this experience to strengthen the integration between chemistry and biophysics, enabling a deeper understanding of the mechanisms of gene transfer at the molecular level. Beyond the scientific goals, I see this visiting period as an opportunity to build a truly shared research environment between Paris and Milan, fostering the exchange of knowledge, methods, and young researchers, as well as shared educational activities, within the 4EU+ community."